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Indicated for: Epilepsy (Lennox-Gastaut Syndrome, Akinetic Seizures, Myoclonic Seizures, Absence Seizures, Focal Seizures, Infantile Spasms), Panic Disorder with or without Agoraphobia, Generalized Anxiety Disorder (Short-term Adjunctive Therapy), Restless Legs Syndrome (Refractory), Rapid Eye Movement Sleep Behavior Disorder, Acute Mania (Adjunctive), Neuroleptic-Induced Akathisia, Acute Alcohol Withdrawal Syndrome, Sleep Bruxism, Trigeminal Neuralgia (Off-label Adjunctive), Stiff Person Syndrome.
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The profound subjective distress of akathisia, the component that drives patients to describe it as worse than any physical pain they have ever endured, is thought to arise from the involvement of the limbic system, the brain's emotional and motivational core, in this same dysregulated circuitry. A neurologist at a major teaching hospital in London or Edinburgh, caring for a patient whose trigeminal neuralgia is only partially responsive to the first-line anticonvulsant carbamazepine, or who is experiencing intolerable side effects such as profound dizziness and cognitive clouding at the higher doses of carbamazepine required for pain control, may elect to add a low dose of Klonopin as an adjunctive agent. Once this acute, high-acuity phase has been safely and successfully navigated and the patient's profound autonomic storm has begun to demonstrably subside, the supervising addiction medicine specialist may elect to transition the patient to a stable, tapering, and more pharmacokinetically predictable regimen of Klonopin.
Ativan Liquid Cost. In terms of clinical potency, a 1 mg dose of Klonopin is generally considered to be roughly equivalent in its anxiolytic effect to a 2 mg dose of Ativan, a 2:1 potency ratio that the prescribing clinician in the United States or Canada must carefully consider when transitioning a patient from one of these agents to the other.
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